In a recent mouse study fisetin has been found to clear senescent cells. The study can be found in EBioMedicine which was published by the prestigious LANCET; “Fisetin is a senotherapeutic that extends health and lifespan”.
With age cells increasingly enter a state of senescence, normally apoptosis and the immune system clear these cells away, but these systems decline with age leaving increasing numbers to accumulate and emit a range of harmful pro-inflammatory signals leading to nearby cells entering the same state, impaired tissue repair, chronic inflammation, progression of osteoarthritis, atherosclerosis, cancer, other age related diseases, and aging itself.
