Scientists uncover protective role of NAD maintenance in kidney disease


Roughly one million people die of untreated kidney failure, worldwide, each year. Despite the major personal and economic burden, only a few new approaches have been deployed to treat or cure kidney disease over the last 40 years.

Metabolic changes related to an enzyme “helper molecule”—called nicotinamide adenine dinucleotide (NAD)—may serve as the basis for a future treatment or preventive measure for kidney disease, according to a discovery by a new study led by researches in the Perelman School of Medicine at the University of Pennsylvania.

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