A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC — a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione — could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging.
Published in the journal Clinical and Translational Medicine, the results of this study show that older humans taking GlyNAC for 24 weeks saw improvements in many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, genomic toxicity, muscle strength, gait speed, exercise capacity and cognitive function. The benefits declined after stopping supplementation for 12 weeks. GlyNAC supplementation was well tolerated during the study period.
