Many people do not want to take a prescription cholesterol medication like a statin but wonder how effective a plant diet can be for lowering serum LDL cholesterol levels. My integrative and preventive cardiology practice attracts patients who either have not tolerated prior medical therapies for elevated cholesterol levels or who choose alternatives to prescription medications. I first seek to determine if they have any evidence of atherosclerosis and then advise them on personalized goals and natural approaches. I emphasize a whole food, plant diet without added oils (WFPBNO) as the foundation of the natural approach and add in supplements as needed. How quickly and to what degree can that diet be effective?