Maternal obesity increases the chance of liver cancer in offspring for generations

Scientists recognize the connection between maternal obesity and liver cancer in the offspring of obese mothers, however, the mechanism is not well understood. In a novel study, appearing in the Journal of Hepatology, investigators have identified a microRNA in obese mouse mothers that appears to pass on liver cancer susceptibility, increasing the odds of liver cancer developing in their offspring and throughout future generations.

One third of the world population is overweight or obese and this global obesity epidemic is threatening human health. Obesity confers a higher risk of developing metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Up to 50 percent of recently diagnosed HCC in the United States is the result of hepatic metabolic disorders such as NAFLD.

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