Most attempts to show that oxidative damage is relevant for aging have not been successful, including many trials with antioxidant compounds. Because of this, although the accumulation of oxidative damage with aging is uncontested, most scientists believe that it is merely a minor, almost inconsequential, cause of aging. A team of scientists from the Spanish National Cancer Research Centre (CNIO) headed by Manuel Serrano, in collaboration with a group from the University of Valencia, directed by José Viña, and researchers at IMDEA Food from Madrid, have attempted to increase the global antioxidant capacity of the cells, instead of just one or a few antioxidant enzymes. They concentrated on increasing the levels of NADPH, which is a simple molecule that is of prime importance in antioxidant reactions, yet has also had not been yet studied in relation to aging. They employed a genetic approach to increase NADPH levels, generating transgenic mice with an increased expression throughout their bodies of one of the most crucial enzymes for the production of NADPH, glucose-6-phosphate dehydrogenase (otherwise known as G6PD).